Immune analysis according to Lauren type for gastric cancer and its significance in individual treatment and prognostic prediction
Diffuse-type tumors exhibited greater immune cell abundance but reduced functional activity, contributing to poorer prognosis. These tumors also demonstrated potentially higher sensitivity to immunotherapy and chemotherapy compared to intestinal-type tumors. HER2-targeted therapy combined with chemoradiotherapy is strongly recommended for intestinal-type GC patients. These disparities are primarily attributable to upregulated LINC00702, C8orf88, and FILP1 in diffuse-type GC patients.
Authors
- Junqiao Yao
- Baojun Huang (ORCID: https://orcid.org/0000-0002-9855-1147)
- Xue Chi
- Huiwen Lu
- Rui Huang (ORCID: https://orcid.org/0000-0002-3048-2835)
Institutions
- Tianjin First Center Hospital (CN)
- First Hospital of China Medical University (CN)
- Tianjin Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1589513
- Citations
- 2
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01