NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer
This work demonstrated that NKEVs can be successfully harvested from patient derived, expanded NK cells, and highlights their heterogeneous cargo, and anti-tumor properties in combination with standard-of-care therapies.
Authors
- Jennifer Finholt
- Taylor Bargenquast
- George J. Snipes
- Kendall R. Van Keuren‐Jensen (ORCID: https://orcid.org/0000-0001-8833-6323)
- Nanyun Tang (ORCID: https://orcid.org/0000-0001-8184-2709)
- Eric B. Alsop (ORCID: https://orcid.org/0000-0002-2717-7573)
- Tithi Ghosh (ORCID: https://orcid.org/0000-0002-4292-1153)
- Joanna Palade
- Michael E. Berens (ORCID: https://orcid.org/0000-0002-3382-6787)
- Ronan J. Kelly (ORCID: https://orcid.org/0000-0002-6446-2103)
- Raffaella Soldi (ORCID: https://orcid.org/0000-0002-2176-3694)
- Jerry Antone
- Timothy G. Whitsett (ORCID: https://orcid.org/0000-0002-0447-5682)
- Gary Schwartz (ORCID: https://orcid.org/0000-0001-9085-1519)
- Sunil Sharma (ORCID: https://orcid.org/0000-0001-7295-0441)
- Dorothy M Paredes
Institutions
- Translational Genomics Research Institute (US)
- Baylor University Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1633010
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61