Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults
PBL profiles exhibit marked heterogeneity at the extremes of age, with infants showing abundant naïve and memory T cell reserves, while older adults are characterized by increased NK cell activity. The age-dependent polarization of the CD4<sup>+</sup>/CD8<sup>+</sup> ratio may serve as a potential biomarker of immunosenescence, offering valuable reference points for age-tailored vaccination strategies and immune risk stratification in the elderly.
Authors
- Ting Ge
- Baohui Wang (ORCID: https://orcid.org/0000-0003-2547-9954)
- Shuangcui Wang (ORCID: https://orcid.org/0000-0002-3685-517X)
- Wentao Li (ORCID: https://orcid.org/0000-0002-5367-3482)
- Jianchun Yu (ORCID: https://orcid.org/0000-0002-4087-2140)
- Juan Zhou (ORCID: https://orcid.org/0000-0003-2500-6110)
- Zekun Wang (ORCID: https://orcid.org/0000-0003-1421-378X)
- Guixin He
- Yingying Xie (ORCID: https://orcid.org/0000-0001-7575-6185)
- Yuanyuan Tian (ORCID: https://orcid.org/0000-0003-1739-3579)
- Qian Cui (ORCID: https://orcid.org/0000-0001-7973-9649)
- Keming Zhang (ORCID: https://orcid.org/0000-0001-8636-1728)
Institutions
- Zhejiang Chinese Medical University (CN)
- Tianjin University of Traditional Chinese Medicine (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- New York University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1599515
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59