Proteomic profiling of cerebrospinal fluid reveals pathophysiology changes and diversity of treatment response in pediatric <i>Streptococcus pneumoniae</i> meningitis
This study establishes CSF proteomic signatures of pediatric SPM, providing dual-purpose biomarker panels for clinical diagnosis and treatment monitoring, with implications for targeted interventions.
Authors
- Liang Zhu (ORCID: https://orcid.org/0000-0002-6529-5706)
- Peng Guo (ORCID: https://orcid.org/0000-0002-5435-5523)
- Yuncui Yu
- Xixi Zhang (ORCID: https://orcid.org/0000-0002-0944-2214)
- Kai Zhu (ORCID: https://orcid.org/0000-0001-9138-0878)
- Binglin Jian
- Lulu Jia (ORCID: https://orcid.org/0000-0002-3453-353X)
- Zhengguang Guo (ORCID: https://orcid.org/0000-0002-5983-7759)
- Linyun Guo (ORCID: https://orcid.org/0009-0007-2342-5510)
- Yunyan Wu
- Gang Liu (ORCID: https://orcid.org/0000-0003-2492-4833)
- Juan Du (ORCID: https://orcid.org/0000-0001-6199-0157)
- Wei Sun (ORCID: https://orcid.org/0000-0002-1493-8249)
- Jing Wei (ORCID: https://orcid.org/0000-0001-7457-0688)
Institutions
- Academy of Medical Sciences (GB)
- Capital University (US)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Center for Children (US)
- Beijing Children’s Hospital (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Expert Review of Proteomics
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1080/14789450.2025.2538654
- Citations
- 1
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China