Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis
This study supports a causal link between insomnia and osteoporosis. Hypothyroidism plays a mediating role in this pathway. Targeting hypothyroidism may lower the risk of osteoporosis associated with insomnia.
Authors
- Hengheng Zhang (ORCID: https://orcid.org/0000-0001-5872-5985)
- Dingyu Wang (ORCID: https://orcid.org/0000-0003-4870-777X)
- Li Y (ORCID: https://orcid.org/0000-0001-6102-2949)
- Lei Wu (ORCID: https://orcid.org/0000-0001-7793-5486)
- Jinxin Tang
- Liyan Zhu (ORCID: https://orcid.org/0000-0002-1639-0598)
Institutions
- Qinghai University (CN)
- Qinghai University Affiliated Hospital (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.exger.2025.112842
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00