Effective RNA Complexation by [2]Catenanes Confers Enhanced Resistance to Enzymatic Degradation
Cationic [2]catenanes bearing l-arginine residues were synthesized via dynamic covalent self-assembly in water. These peptide-based mechanically interlocked molecules (MIMs) exhibit proteolytic stability, efficiently complex small-interfering RNA (siRNA), and protect it from nuclease degradation. Their performance in siRNA binding is attributed to multivalency and preorganization enforced by the mechanical bond.
Authors
- Dominique Delcourt (ORCID: https://orcid.org/0000-0002-2197-212X)
- Fabien B. L. Cougnon (ORCID: https://orcid.org/0000-0003-4487-8707)
- Sébastien Ulrich (ORCID: https://orcid.org/0000-0002-6080-3345)
- José García Coll (ORCID: https://orcid.org/0000-0002-6012-7287)
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Montpellier (FR)
- Institut des Biomolécules Max Mousseron (FR)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1002/chem.202501631
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Jyväskylän Yliopisto
- Université de Montpellier