A laboratory test to detect gliadin-specific CD4+ T-cells for difficult to diagnose celiac disease
Gliadin-specific T-cells can be detected in peripheral blood of CD patients using commercially available dextramers. These cells persist in CD patients on a GFD but may decline over time. A short term low-dose gluten challenge increased sensitivity. This simplified detection method of gliadin-specific T-cells is suitable for diagnostic challenging CD cases.
Authors
- Nicolette Wierdsma (ORCID: https://orcid.org/0000-0002-0125-0680)
- Hetty J. Bontkes (ORCID: https://orcid.org/0000-0002-3562-293X)
- Jolien C. Hollander
- Kim de Buck
- Daan A R Castelijn (ORCID: https://orcid.org/0000-0001-7422-3387)
- Tracy-Jane T. H. D. Eisden
- Marianne B. M. van den Bree (ORCID: https://orcid.org/0000-0002-4426-3254)
- Gerd Bouma (ORCID: https://orcid.org/0000-0002-0084-5092)
Institutions
- St. Antonius Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100301
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Maag Lever Darm Stichting