Integrated network toxicology and bioinformatics reveal PFAS-driven prognostic biomarkers and molecular mechanisms in breast cancer: insights from transcriptome analysis and molecular docking
PFAS exposure is linked to altered gene expression, immune cell infiltration, and potential disruptions in key genes, contributing to breast cancer development and progression. These findings provide insights into potential therapeutic targets and underline the importance of addressing environmental factors in breast cancer management.
Authors
- Yingqiang Fu (ORCID: https://orcid.org/0000-0001-8222-5825)
- Ziqi Sui (ORCID: https://orcid.org/0000-0002-6764-8608)
- Yiyang Liu (ORCID: https://orcid.org/0000-0002-2356-8294)
Institutions
- Zhejiang Chinese Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s12672-025-03084-z
- Citations
- 1
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.86