96-h methamphetamine self-administration elicits striatal dopamine depletion in male and female rats: a model of binge-like use
These findings demonstrate that volitional methamphetamine intake under a 96-h access model induces robust dopaminergic deficits, paralleling those seen in non-contingent binge dosing. This model provides a translationally relevant paradigm, capturing both the behavioral and neurobiological aspects of human methamphetamine use, supporting its utility for investigating neurotoxicity and potential treatments.
Authors
- Bo Jarrett Wood (ORCID: https://orcid.org/0000-0002-3893-260X)
- Robert D. Dayton (ORCID: https://orcid.org/0009-0003-8663-2032)
- Nicholas E. Goeders (ORCID: https://orcid.org/0000-0002-2452-4867)
- Nicole Hall (ORCID: https://orcid.org/0000-0002-4936-3043)
- Courtney M. Keller
- Kevin S. Murnane (ORCID: https://orcid.org/0000-0002-8143-0541)
- Christopher E. Cannon
- Ethan D Brackett
Institutions
- Louisiana State University in Shreveport (US)
- Louisiana State University Health Sciences Center Shreveport (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s00213-025-06850-7
- Citations
- 1
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Louisiana State University
- Agricultural Center, Louisiana State University
- National Institute on Drug Abuse