Contribution of white matter microstructure to diffusion tensor image analysis along perivascular space in obstructive sleep apnea
These findings suggest that the ALPS index is influenced by both diffusivity along perivascular spaces and white matter microstructure, particularly commissural fibres. Although it should not be regarded as a highly specific marker of perivascular space function, variant indices support partial perivascular contribution. Furthermore, associations with sleep and neurofluid-related metrics imply that white matter architecture and inter-fibre spaces may serve as plausible routes for interstitial fluid flow.
Authors
- Toshiki Nakane (ORCID: https://orcid.org/0000-0002-0383-2879)
- Shinji Naganawa
- Nobuyasu Ichinose (ORCID: https://orcid.org/0000-0001-6580-5086)
- Rei Nakamichi (ORCID: https://orcid.org/0000-0001-6933-0954)
- Toshiaki Taoka (ORCID: https://orcid.org/0000-0001-9227-0240)
- Rintaro Ito (ORCID: https://orcid.org/0000-0002-7971-043X)
- Junko Kikuta (ORCID: https://orcid.org/0000-0003-1324-8614)
- Seiko Miyata (ORCID: https://orcid.org/0000-0002-1144-5676)
- Hiroshige Fujishiro (ORCID: https://orcid.org/0000-0001-9822-5432)
- Kunihiro Iwamoto (ORCID: https://orcid.org/0000-0003-3868-3372)
- Masashi Ikeda (ORCID: https://orcid.org/0000-0001-6237-2449)
- Mami Iima (ORCID: https://orcid.org/0000-0002-1991-2494)
- Koji Kamagata (ORCID: https://orcid.org/0000-0001-5028-218X)
- Shigeki Aoki (ORCID: https://orcid.org/0000-0003-2821-0651)
- Kazushige Ichikawa
- Akifumi Kamiunten
Institutions
- Canon (Japan) (JP)
- Juntendo University (JP)
- Nagoya University Hospital (JP)
- Canon Medical Systems Corporation (Japan) (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Japanese Journal of Radiology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s11604-025-01838-x
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- Nagoya University
- Japan Society for the Promotion of Science