Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells
Taken together, HCIE suppresses inflammation mediators through the regulation of the MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathways, while up-regulating skin moisturizing factors in keratinocytes. These results suggest that HCIE may be utilized in the treatment of skin inflammatory diseases, such as AD.
Authors
- Mansoo Cho
- Oh-Kyung Kwon (ORCID: https://orcid.org/0000-0003-0737-5422)
- Hyun‐Ju Jung (ORCID: https://orcid.org/0000-0002-2756-0644)
- Seok‐Seong Kang (ORCID: https://orcid.org/0000-0001-7029-9122)
- Sun Up Noh
- Hyun Ji Choi (ORCID: https://orcid.org/0000-0002-4161-0708)
- Yun Jung Lee (ORCID: https://orcid.org/0000-0002-9347-8606)
- Jiye Han
- Do-Won Lim
Institutions
- Kookmin University (KR)
- Cheongju University (KR)
- WonKwang Health Science University (KR)
- Wonkwang University (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fphar.2025.1617180
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Rural Development Administration