Prognostic Significance of Somatic Mutations in Myeloid Cells of Men with Chronic Heart Failure – Interaction Between Loss of Y Chromosome and Clonal Haematopoiesis
Somatic mutations in blood cells-particularly LOY-are associated with increased mortality in male CHF patients, with LOY emerging as an independent prognostic marker.
Authors
- Wesley Abplanalp (ORCID: https://orcid.org/0000-0001-5996-8997)
- David M. Leistner (ORCID: https://orcid.org/0000-0002-4351-420X)
- Heribert Schunkert (ORCID: https://orcid.org/0000-0001-6428-3001)
- Johannes Krefting (ORCID: https://orcid.org/0000-0002-7755-0954)
- Stefanie Dimmeler (ORCID: https://orcid.org/0000-0002-1045-2436)
- Thimoteus Speer (ORCID: https://orcid.org/0000-0002-2491-6393)
- Alexander Berkowitsch
- Andreas M. Zeiher (ORCID: https://orcid.org/0000-0003-1711-5819)
- Akshay Pramod Ware (ORCID: https://orcid.org/0000-0002-3783-8291)
- Klara Kirschbaum (ORCID: https://orcid.org/0000-0002-4065-600X)
- Silvia Mas‐Peiró (ORCID: https://orcid.org/0000-0002-3828-8180)
- Tina Rasper
- Moritz von Scheidt (ORCID: https://orcid.org/0000-0001-7159-8271)
- Sebastian Cremer (ORCID: https://orcid.org/0000-0002-6409-9279)
- Lukas Tombor (ORCID: https://orcid.org/0000-0002-5867-576X)
- Andrin Schuff
Institutions
- Goethe University Frankfurt (DE)
- Goethe-Institute United Kingdom (GB)
- Fresenius (Germany) (DE)
- German Centre for Cardiovascular Research (DE)
- University Hospital Frankfurt (DE)
- Deutsches Herzzentrum München (DE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1002/ejhf.3778
- Citations
- 5
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 8.85
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Corona-Stiftung
- European Commission
- Deutsche Forschungsgemeinschaft