Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer
The findings indicate that CTSS negatively regulates IL-7 secretion by interacting with IL-7R. The CTSS-targeting strategy has the potential to reinvigorate IL-7-directed anti-tumor T cell immunity and enhance the therapeutic effect of the anti-PD-1 antibody.
Authors
- Hsing‐Pang Hsieh (ORCID: https://orcid.org/0000-0002-1332-005X)
- Szu-Jung Chen
- Sheng-Yen Hsiao
- Wei‐Fan Chiang (ORCID: https://orcid.org/0000-0002-9240-1404)
- Shang‐Hung Chen (ORCID: https://orcid.org/0000-0002-4086-4757)
- Wen-Yun Hsueh
- Jenn‐Ren Hsiao (ORCID: https://orcid.org/0000-0001-8801-3866)
- Yung-Chieh Chang (ORCID: https://orcid.org/0000-0002-8699-2834)
- Chan‐Chuan Liu (ORCID: https://orcid.org/0000-0002-8697-4177)
- Jui–Mei Chu
- Meng‐Ru Shen (ORCID: https://orcid.org/0000-0003-0506-3505)
- Chung‐Hsing Chen (ORCID: https://orcid.org/0000-0002-1205-7368)
- Liying Qiu
- Ya‐Wen Chen (ORCID: https://orcid.org/0000-0003-2382-8444)
- Kwang‐Yu Chang (ORCID: https://orcid.org/0000-0002-5240-2760)
- Jang Yang Chang
- Ko-Jiunn Liu
- Shang-Yin Wu
- Li-Hsien Chen
Institutions
- Chung Hwa University of Medical Technology (TW)
- Albert Einstein College of Medicine (US)
- National Yang Ming Chiao Tung University (TW)
- National Health Research Institutes (TW)
- National Tsing Hua University (TW)
- Taipei Medical University Hospital (TW)
- Chi Mei Medical Center (TW)
- National Cheng Kung University Hospital (TW)
- Taipei Medical University (TW)
- National Cheng Kung University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Taipei University (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s12929-025-01154-6
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education
- National Health Research Institutes