Analysis of Transdermal Distribution and Blood Components in Guinea Pigs Following the Application of Bai Jie Zi San Using Matrix‐Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Ultra‐High‐Performance Liquid Chromatography‐Quadrupo
The study demonstrated that combining MALDI-MSI with UHPLC-Q-TOF-MS technology offered an intuitive, straightforward, and reliable approach to effectively reflect the distribution characteristics of transdermal components and identify the types of components entering the bloodstream after the application of BJZS. These findings provided valuable insights into the pharmacological mechanisms and modern development of this traditional Chinese herbal formula.
Authors
- Lei-Bing Xue
- Yeqing Chen (ORCID: https://orcid.org/0000-0002-5602-3311)
- Chun Zhang (ORCID: https://orcid.org/0000-0003-3565-8024)
- Xiaoliang Fan (ORCID: https://orcid.org/0000-0001-5105-1797)
- Jia Zheng (ORCID: https://orcid.org/0009-0004-0893-9327)
- Tianhong Ma
- Mengxuan Chen (ORCID: https://orcid.org/0000-0001-9676-4598)
- Yanhui Shen
Institutions
- Jiaxing University (CN)
- Shimadzu (China) (CN)
- First Hospital of Jiaxing (CN)
- ZheJiang Institute For Food and Drug Control (CN)
Publication Details
- Journal
- Phytochemical Analysis
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1002/pca.70016
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00