Mycophenolate mofetil‐induced colitis versus colonic graft‐versus‐host disease: a comparative histologic study with artificial intelligence model development
Lower eosinophil counts, higher apoptotic counts and neuroendocrine cell aggregates favour the diagnosis of GVHD. AI models for eosinophil quantification may serve as an ancillary tool for assessing this differential diagnosis. Given the rarity of MMF-induced colitis in SCT patients, pathologists should have a high threshold for making this diagnosis in this population.
Authors
- Rofyda Elhalaby (ORCID: https://orcid.org/0000-0001-6990-8154)
- Catherine E. Hagen (ORCID: https://orcid.org/0000-0002-1867-4957)
- Won‐Tak Choi (ORCID: https://orcid.org/0000-0002-6892-5881)
- Benjamin J. Van Treeck (ORCID: https://orcid.org/0000-0001-9720-1674)
- Huaibin M. Ko (ORCID: https://orcid.org/0000-0003-1062-2383)
- Christopher Hartley (ORCID: https://orcid.org/0000-0002-2237-3102)
- Priyadharshini Sivasubramaniam (ORCID: https://orcid.org/0000-0001-6058-2688)
- Nadarra Stokes (ORCID: https://orcid.org/0000-0001-9374-0531)
- Roger K. Moreira (ORCID: https://orcid.org/0000-0001-6087-8366)
- Lindsey Smith
Institutions
- Mayo Clinic (US)
- University of California, San Francisco (US)
- Medical College of Wisconsin (US)
- Tanta University (EG)
- University of Alabama at Birmingham (US)
- University Pathologists (US)
- Columbia University (US)
Publication Details
- Journal
- Histopathology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1111/his.15521
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mayo Clinic