Developmental Endothelial Locus 1 Reduces Traumatic Brain Injury–Induced Endotheliopathy and Dysregulated Coagulation in Mice
This study demonstrates the importance of reducing anionic phospholipid-expressing EVs for TBI resuscitation and identifies Del-1 as a potential therapeutic agent to reduce EV-induced endotheliopathy and coagulopathy.
Authors
- Xiaoyang Zhang (ORCID: https://orcid.org/0009-0004-2990-6313)
- Jessica C. Cardenas (ORCID: https://orcid.org/0000-0001-6668-1054)
- Yuan Zhou (ORCID: https://orcid.org/0000-0003-1962-2574)
- Perumal Thiagarajan (ORCID: https://orcid.org/0000-0003-2186-7036)
- Yafan Liu (ORCID: https://orcid.org/0000-0002-4200-0098)
- Jing‐fei Dong (ORCID: https://orcid.org/0000-0001-6379-4133)
- Charles E. Wade (ORCID: https://orcid.org/0000-0003-0055-5885)
- Tianrui Ma (ORCID: https://orcid.org/0000-0003-0894-6653)
- Zilong Zhao (ORCID: https://orcid.org/0000-0001-8218-6395)
- Li Yang (ORCID: https://orcid.org/0000-0003-2716-3793)
- Min Li (ORCID: https://orcid.org/0000-0001-9228-6672)
- Zijian Zhou (ORCID: https://orcid.org/0000-0003-1382-6293)
- Yuyang Miao (ORCID: https://orcid.org/0000-0002-4453-9687)
- Guili Yang (ORCID: https://orcid.org/0000-0003-4411-7043)
- Jianning Zhang (ORCID: https://orcid.org/0000-0002-6733-8511)
- Lujia Tang
- Min Wang (ORCID: https://orcid.org/0000-0002-8905-6857)
- Jianlong Men
- Li Liu (ORCID: https://orcid.org/0000-0002-0504-418X)
Institutions
- Michael E. DeBakey VA Medical Center (US)
- University of Washington (US)
- Bloodworks Northwest (US)
- Tianjin Medical University General Hospital (CN)
- Karolinska Institutet (SE)
- The University of Texas Health Science Center (US)
- Lanzhou University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1161/atvbaha.125.322515
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00