Evaluating the Effects of Nusinersen Treatment in Adults With Spinal Muscular Atrophy Using Axonal Excitability and <scp>MscanFit MUNE</scp>

A prolongation of SDTC, likely due to its effect on sodium channel function, was observed in this study, consistent with existing literature. Despite improvements in motor function, no significant electrophysiological changes were detected in adult SMA patients.

Authors

Hilmi Uysal (ORCID: https://orcid.org/0000-0002-6063-377X)
Nazan Şimşek Erdem
Abir Alaamel (ORCID: https://orcid.org/0000-0003-4032-0247)
Hulusi Ekber KAYA (ORCID: https://orcid.org/0000-0002-2097-7893)
Gökçe Yağmur Güneş Gencer (ORCID: https://orcid.org/0000-0001-8651-8318)

Institutions

Akdeniz University (TR)
Antalya Eğitim ve Araştırma Hastanesi (TR)
Antalya IVF (TR)

Publication Details

Journal: Muscle & Nerve
Published: 2025-07-24
DOI: https://doi.org/10.1002/mus.28476
Citations: 2
Primary Topic: Neurogenetic and Muscular Disorders Research
Type: article
Field-Weighted Citation Impact: 3.25

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article

Evaluating the Effects of Nusinersen Treatment in Adults With Spinal Muscular Atrophy Using Axonal Excitability and MscanFit MUNE

Hilmi Uysal, Nazan Şimşek Erdem, Abir Alaamel, Hulusi Ekber KAYA et al.

Jul 24, 2025

2 citations

Muscle & Nerve

Neurogenetic and Muscular Disorders Research

3.25

article

Evaluating the Effects of Nusinersen Treatment in Adults With Spinal Muscular Atrophy Using Axonal Excitability and MscanFit MUNE

Hilmi Uysal, Nazan Şimşek Erdem, Abir Alaamel, Hulusi Ekber KAYA, Gökçe Yağmur Güneş Gencer

July 24, 2025article en

2 citations

Abstract

A prolongation of SDTC, likely due to its effect on sodium channel function, was observed in this study, consistent with existing literature. Despite improvements in motor function, no significant electrophysiological changes were detected in adult SMA patients.

Muscle & NerveVol. 72(3)

Akdeniz University (TR), Antalya Eğitim ve Araştırma Hastanesi (TR), Antalya IVF (TR)

Openalex Percentile: Top 8%

Neurogenetic and Muscular Disorders Research

3.25

DOI Open Access PDF OpenAlex

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