A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML
This multi-omics study provides unprecedented insights into the transcriptional and epigenetic heterogeneity of t(8;21) AML, providing a potential actionable tool for clinical risk stratification.
Authors
- Yang Liang (ORCID: https://orcid.org/0000-0002-4666-9653)
- Yuting Dai (ORCID: https://orcid.org/0000-0001-8275-2115)
- Jiaying Mao
- Baitian Zhao
- Xue‐Ping Li (ORCID: https://orcid.org/0000-0002-4588-065X)
- Lu Jiang (ORCID: https://orcid.org/0000-0003-1816-0523)
- Yan Gao (ORCID: https://orcid.org/0000-0002-1268-2999)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s12967-025-06659-0
- Citations
- 6
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- Fundamental Research Funds for the Central Universities