Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
Low CD4+ and CD8+ T cell values were associated with severe clinical presentation, more need for oxygen therapy as well as poor disease outcome. Receiver operating characteristic analysis provided cutoff values to support predicting the aforementioned variables, establishing CD4+ and CD8+ values as significant prognostic biomarkers. Future studies should be aimed at identifying factors that lead to gender differences in the immune response.
Authors
- Sara Petrović (ORCID: https://orcid.org/0000-0001-6313-3749)
- Jagoda Gavrilović (ORCID: https://orcid.org/0000-0003-3327-3884)
- Nemanja Đorđević (ORCID: https://orcid.org/0000-0002-6161-4925)
- N Stanković (ORCID: https://orcid.org/0000-0002-1371-6169)
- Ana Divjak (ORCID: https://orcid.org/0000-0002-9989-1426)
- Ivana Raković (ORCID: https://orcid.org/0000-0002-3406-1587)
- Katarina Milosavljevic
- Miloš Milosavljević (ORCID: https://orcid.org/0000-0003-4201-0269)
- Ružica Radojević Marjanović
- Predrag Čanović (ORCID: https://orcid.org/0000-0002-2144-4263)
- Milan Paunović (ORCID: https://orcid.org/0000-0002-8414-5674)
- Biljana Popovska Jovičić (ORCID: https://orcid.org/0000-0001-9280-2251)
Institutions
- University of Kragujevac (RS)
- Clinical Centre of Kragujevac (RS)
Publication Details
- Journal
- Open Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/med-2025-1246
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00