ORAI1, FGF23, PP13, palladin, and supervillin as potential biomarkers in late-onset pre-eclampsia: a comparative study in maternal and cord blood

The altered expression of ORAI1, FGF23, and PP13 in late-onset pre-eclampsia suggests disruptions in calcium signaling, phosphate metabolism, and placental function. The parallel measurement of these proteins in both maternal and cord blood provided unique insights into maternal-fetal interface dysfunction in pre-eclampsia. The superior performance of combined ORAI1 and FGF23 measurement underscores the value of a multi-marker approach in capturing pre-eclampsia's complex pathophysiology, potentially contributing to improved diagnostic strategies and therapeutic interventions.