Triage of women with a positive HPV DNA test: evaluating a DNA methylation panel for detecting cervical intraepithelial neoplasia grade 3 and cervical cancer in cervical cytology samples
ZNF671<sup>m</sup> within the GynTect® panel demonstrates robust triage performance in diagnosing CIN3 + cases, with efficacy comparable to the full panel. These findings suggest that ZNF671<sup>m</sup> could be a promising alternative for cytologic triage, warranting further validation.
Authors
- Yifei Ren (ORCID: https://orcid.org/0000-0002-6081-7392)
- Feifei Qin (ORCID: https://orcid.org/0000-0001-7161-1173)
- L. Li
- Qingrong Wu
- Li Shen (ORCID: https://orcid.org/0000-0002-1263-2940)
- Ping Yi (ORCID: https://orcid.org/0000-0002-3213-6717)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- Fuling Center Hospital of Chongqing (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s12885-025-14531-z
- Citations
- 3
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Chongqing Medical University