SERUM LIVER MARKERS ASSOCIATED WITH FEATURES OF METABOLOC SYNDROME IN THE WORKING-AGE POPULATION

Cardiometabolic syndrome is a chronic condition characterised by the presence of at least three of the following conditions: elevated fasting glucose, central obesity, hypertension, high triglycerides, and low HDL levels, that collectively increase t he risk of cardiovascular disease and diabetes.This study aims to determine the prevalence of metabolic syndrome among working-age individuals and identify related factors to inform targeted interventions.Conducted over nine months at the National Institute of Medical Assessment and Work Capacity Rehabilitation in Bucharest, the observational study involved 332 individuals with abnormal liver and lipid test results.The mean age was 53.09 years, with a male -to-female ratio of 2.46.Over half (52.11%) met the criteria for metabolic syndrome.Obesity was notably prevalent and significantly associated with dyslipidaemia (66.67%, p = 0.026) and metabolic syndrome (59.72%, p < 0.001).Elevated levels of AST (p = 0.037), GGT (p = 0.001), and triglycerides (p = 0.025) were observed in obese patients.These findings highlight the strong association between obesity and metabolic syndrome, suggesting that liver enzymes like AST and GGT may serve as valuable biomarkers and potential therapeutic targets in managing the syndrome. RezumatSindromul cardiometabolic este o afeciune cronic caracterizat prin prezena a cel puin trei dintre urmtoarele condiii: hiperglicemie, obezitate central, hipertensiune arterial, trigliceride crescute i niveluri sczute de HDL-colesterol, care mpreun cresc riscul de boli cardiovasculare i diabet.Acest studiu are drept scop determinarea prevalenei sindromului metabolic n rndul persoanelor de vrst activ i identificarea factorilor asociai pentru a argumenta posibile intervenii specifice.Realizat pe parcursul a nou luni la Institutul Naional de Expertiza Medical i Recuperare a Capacitii de Munc din Bucureti, in studiul observaional au fost incluse 332 de persoane cu rezultate anormale ale testelor hepatice i lipidice.Vrsta medie a fost de 53,09 ani, cu un raport brbai-femei de 2,46.Peste jumtate (52,11%) au ndeplinit criteriile pentru sindromul metabolic.Obezitatea a fost deosebit de frecventa i semnificativ asociat cu dislipidemia (66,67%, p = 0,026) i sindromul metabolic (59,72%, p < 0,001).La pacienii obezi s-au observat niveluri crescute de AST (p = 0,037), GGT (p = 0,001) i trigliceride (p = 0,025).Aceste constatri evideniaz asocierea putern ic dintre obezitate i sindromul metabolic, sugernd c enzimele hepatice, precum AST i GGT, pot servi drept biomarkeri utili i poteniale inte terapeutice n gestion area acestui sindrom.