EFFICACY OF SALVIA MILTIORRHIZA EXTRACT INJECTION ON PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH CORONARY ATHEROSCLEROTIC HEART DISEASE

Salvia miltiorrhiza extract, rich in salvianolic acid, has anti-inflammatory and microcirculatory benefits.This study evaluated its effects in coronary atherosclerotic heart disease (CAHD) patients' post-percutaneous coronary intervention (PCI).One hundred patients were randomised into a control group (CG) receiving isosorbide dinitrate and an experimental group (EG) receiving Salvia miltiorrhiza extract in addition.EG showed a higher treatment success rate (92% vs. 74%) and greater improvements in heart rate, angina, cardiac function, lipid profile, endothelial function and cardiovascular biomarkers.Significant reductions were observed in LDL-C, troponin, CK-MB, hs-CRP, GDF-15 and GRACE scores, with better outcomes in the EG.Adverse events were fewer in the EG (p < 0.05).Salvia miltiorrhiza extract injection proved clinically effective in improving cardiovascular outcomes and reducing disease progression in CAHD patients after PCI. RezumatAcest studiu a evaluat efectele administrrii extractului de Salvia miltiorrhiza la pacieni cu boal cardiac aterosclerotic coronarian (CAHD) dup intervenie coronarian percutanat (PCI).O sut de pacieni au fost randomizai ntr-un grup de control (GC), care a primit dinitrat de izosorbid, i un grup experimental (GE), care a primit suplimentar extract injectabil de Salvia miltiorrhiza.Grupul experimental a prezentat o rat mai mare de succes terapeutic (92% fa de 74%) i mbuntiri semnificative ale frecvenei cardiace, simptomatologiei anginoase, funciei cardiace, profilului lipidic, funciei endoteliale i markerilor cardiovasculari.