EFFECTS OF ORAL ASPIRIN AND CALCIUM ON HEMODYNAMICS AND PLACENTAL PATHOLOGICAL CHANGES IN PATIENTS WITH PREGNANCY-INDUCED HYPERTENSION

This study aimed to evaluate the effects of oral aspirin and calcium supplementation on hemodynamic parameters and placental pathology in patients with pregnancy-induced hypertension (PIH), and to assess their potential role in PIH management.A total of 210 pregnant women with a positive PIH prediction were retrospectively divided into three groups: control (n = 96), mild (n = 66), and severe (n = 48).The mild group received routine care plus vitamin C (1g/day), vitamin E (50 mg/day), and vitamin D-calcium chewable tablets (600 mg calcium + 400 IU vitamin D).The severe group received the same regimen with the addition of aspirin (100 mg/day).Hemodynamic parameters, coagulation indexes, middle cerebral artery and umbilical artery resistance indices (RI), placental histology, and clinical outcomes were assessed before treatment, after 5 weeks, and prior to delivery.Significant improvements in hemodynamic and coagulation parameters and RI values were observed post-treatment in the severe group compared to the mild group (p < 0.05).Caesarean rates and complications such as postpartum haemorrhage, placental abruption, and foetal distress were notably reduced in the severe group.Overall, oral aspirin and calcium supplementation improved maternal-foetal outcomes by enhancing hemodynamic and placental function, offering valuable guidance for the clinical management of PIH. RezumatAcest studiu a evaluat efectele administrrii orale de aspirin i calciu asupra parametrilor hemodinamici i a leziunilor placentare la gravidele cu hipertensiune indus de sarcin (PIH).Astfel, 210 femei nsrcinate, cu risc crescut de PIH au fost mprite n trei grupuri: control (n = 96), form uoar (n = 66) i form sever (n = 48).Grupul cu form uoar a beneficiat de ngrijire standard, completat cu vitamina C (1 g/zi), vitamina E (50 mg/zi) i tablete masticabile cu calciu i vitamina D (600 mg calciu + 400 UI vitamina D).Grupul cu form sever a primit acelai tratament, cu suplimentarea regimului prin administrarea de aspirin (100 mg/zi).Parametrii hemodinamici, indicii de coagulare, indicii de rezisten ai arterei cerebrale medii i ai arterei ombilicale, histologia placentar i evoluia clinic au fost monitorizate nainte de tratament, la 5 sptmni i nainte de natere.Comparativ cu grupul cu form uoar, pacientele din grupul sever au prezentat mbuntiri semnificative ale parametrilor hemodinamici, ale indicilor de coagulare i ale fluxurilor vasculare (p < 0,05).De asemenea, s-au nregistrat rate mai mici de natere prin cezarian i o reducere a complicaiilor precum hemoragia postpartum, abruptio placentae i suferin fetal.