CLINICAL EVALUATION OF UNANI FORMULATIONS SHARBAT KHAKSI AND KHAMIRA MARWAREED KHAS IN THE TREATMENT OF TYPHOID FEVER IN RURAL SLUMS OF BURHANPUR

Background:Enteric fever, commonly known as typhoid fever, is a serious communicable systemic illness that primarily affects the gastrointestinal tract and typically persists for 21 days or more. This study aimed to evaluate the clinical effectiveness and community-level awareness of the Unani formulations Sharbat Khaksi and Khamira Marwareed Khas in the management of typhoid fever in the rural slums of Burhanpur. Methods:This was a community-based clinical trial conducted in five rural areas of Burhanpur district. The study was conducted through an OPD-based approach in five rural areas of Burhanpur district under the Tribal Sub Plan (TSP) program, implemented by the Clinical Research Unit (CRU), Burhanpur. A total of 129 patients, clinically diagnosed with typhoid fever at the time of recruitment, were enrolled. Data were collected using a structured questionnaire, and all patients were treated with the Unani formulations Sharbat Khaksi and Khamira Marwareed Khas. Results:Among the 129 participants, 67 (51.9%) were male and 62 (48.1%) were female, reflecting a nearly equal gender distribution. The majority (28.7%) belonged to the 16 30 year age group. The administration of the Unani formulations resulted in statistically significant improvement in clinical symptoms of typhoid fever, supporting their therapeutic efficacy. Conclusion:The study indicates that the Unani formulations Sharbat Khaksi and Khamira Marwareed Khas have significant therapeutic potential in managing typhoid fever. These findings support the integration of validated Unani treatments into public health strategies for the control of enteric infections. Nonetheless, larger, controlled clinical trials are necessary to confirm these results and facilitate their broader clinical application.