Optimizing DNA Sequence Classification via a Deep Learning Hybrid of LSTM and CNN Architecture

This study addresses the performance of deep learning models for predicting human DNA sequence classification through an exploration of ideal feature representation, model architecture, and hyperparameter tuning. It contrasts traditional machine learning with advanced deep learning approaches to ascertain performance with respect to genomic data complexity. A hybrid network combining long short-term memory (LSTM) and convolutional neural networks (CNN) was developed to extract long-distance dependencies as well as local patterns from DNA sequences. The hybrid LSTM + CNN model achieved a classification accuracy of 100%, which is significantly higher than traditional approaches such as logistic regression (45.31%), naïve Bayes (17.80%), and random forest (69.89%), as well as other machine learning models such as XGBoost (81.50%) and k-nearest neighbor (70.77%). Among deep learning techniques, the DeepSea model also accounted for good performance (76.59%), while others like DeepVariant (67.00%) and graph neural networks (30.71%) were relatively lower. Preprocessing techniques, one-hot encoding, and DNA embeddings were mainly at the forefront of transforming sequence data to a compatible form for deep learning. The findings underscore the robustness of hybrid structures in genomic classification tasks and warrant future research on encoding strategy, model and parameter tuning, and hyperparameter tuning to further improve accuracy and generalization in DNA sequence analysis.