Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
Molecular hydrogen confers protection against cisplatin-induced nephrotoxicity by modulating β-HOB metabolism through upregulation of HMGCS2, thereby suppressing renal inflammation and apoptosis. These findings provide new insights into the metabolic mechanism underlying H<sub>2</sub>'s tissue-protective effects and offer a theoretical foundation for its potential clinical application in mitigating chemotherapy-induced kidney injury.
Authors
- Yan Tian (ORCID: https://orcid.org/0000-0002-5927-4706)
- Weiping Fan (ORCID: https://orcid.org/0000-0001-5830-0717)
- Xiujuan Geng (ORCID: https://orcid.org/0000-0003-4953-0208)
- Huilan Su
- Wenjie Tang (ORCID: https://orcid.org/0000-0002-9752-4948)
- Yu Wang (ORCID: https://orcid.org/0000-0003-2989-4944)
- Youzhen Wei (ORCID: https://orcid.org/0000-0002-5634-6073)
- Jianjun Zhou (ORCID: https://orcid.org/0000-0002-0302-6850)
- Yunxi Chen (ORCID: https://orcid.org/0000-0002-0227-2435)
- Yafang Zhang (ORCID: https://orcid.org/0009-0003-5624-862X)
Institutions
- Shanxi Medical University (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s11033-025-10845-0
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00