KarXT combines the partial benefits of haloperidol for positive symptoms and sulpiride for negative symptoms: Evidence from computational biology
This study provides insights into the distinct molecular mechanisms by which haloperidol and sulpiride affect distinct symptoms of schizophrenia. KarXT integrates the partial effects of both drugs, including CASP3 with haloperidol and AKT1 and IGF1 with sulpiride. Our results provide a theoretical basis for clinical applications and new directions for drug development.
Authors
- Ranli Li
- Yachen Li (ORCID: https://orcid.org/0000-0002-3783-4872)
- Qiuyu Zhang (ORCID: https://orcid.org/0009-0000-2794-6777)
- Chuanjun Zhuo (ORCID: https://orcid.org/0000-0002-3793-550X)
- Lei Yang (ORCID: https://orcid.org/0000-0002-2956-0920)
- Ximing Chen (ORCID: https://orcid.org/0000-0002-9079-2755)
- Chao Li (ORCID: https://orcid.org/0009-0005-1200-1726)
- Lina Wang (ORCID: https://orcid.org/0000-0002-5323-5431)
- Xiaoyan Ma (ORCID: https://orcid.org/0009-0007-7953-947X)
- Hongjun Tian (ORCID: https://orcid.org/0000-0002-3919-3749)
Institutions
- Tianjin Anding Hospital (CN)
- Tianjin Fourth Hospital (CN)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1177/02698811251353268
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China