Developing a novel aging assessment model to uncover heterogeneity in organ aging and screening of aging-related drugs
The 2A model represents a significant advancement in aging assessment by integrating multi-dimensional validation strategies, enhancing its accuracy and applicability. The identification of organ-specific aging pathways and candidate pharmacological interventions provides a theoretical foundation and translational framework for precision anti-aging therapies.
Authors
- Yingqi Xu (ORCID: https://orcid.org/0000-0001-6879-639X)
- Xing Gao (ORCID: https://orcid.org/0000-0002-7410-4051)
- Maohao Li
- Congxue Hu
- Xia Li (ORCID: https://orcid.org/0000-0002-9794-2648)
- Yunpeng Zhang (ORCID: https://orcid.org/0000-0001-6208-9571)
- Yawen Luo (ORCID: https://orcid.org/0009-0007-3716-8914)
- Xinyu Li (ORCID: https://orcid.org/0009-0007-0392-1103)
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s13073-025-01501-0
- Citations
- 3
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China