How Does Physical Activity Affect the Mental Health of Adults with Intellectual Disability? A Cross-Sectional Study Analyzing the Complex Interplay Between Variables

<b>Background:</b> Individuals with intellectual disability face an increased risk of mental health issues compared to the general population. Despite the proven efficacy of physical activity (PA) in improving anxiety and depression in the general population, little is known about this relationship in adults with intellectual disability and the factors that influence it. The purpose of the study was to determine whether a correlation exists between PA and perceived levels of anxiety and depression, and assess gender disparities in PA and mental health. <b>Method:</b> People with intellectual disability were recruited from day centers and sports events. The amount of PA was evaluated through the International Physical Activity Questionnaire. Perceived mental health was assessed through the Zung Self-Rating Anxiety (ZAS) and Depression Scale (ZDS). <b>Results:</b> In total, 99 adults (34 females, aged 33 ± 12) participated in the study. A gender disparity was found in anxiety levels, while depression, PA, and type of sport participation did not differ between males and females. Multiple regression analysis highlights how the depression score was significantly predicted by gender (β = -3.57, <i>p</i> = 0.015), intellectual disability level (β =-3.08, <i>p</i> < 0.008), and PA (β =-0.10, <i>p</i>= 0.001), while anxiety was influenced by gender (β = -4.48, <i>p</i> = 0.003) and intellectual disability level (β = -3.23, <i>p</i> = 0.007). <b>Conclusions:</b> These findings underscore the relevance of physical activity as a factor associated with lower depressive symptoms in adults with intellectual disability, highlighting its potential role in mental health promotion within this population.