Severe disseminated nfections in cohabiting people: Genotypic description of methicillin-susceptible Staphylococcus aureus (MSSA) isolate belonging to CC398 clonal complex
In this study, we describe two closely related cases of multifocal MSSA infections within the same household. The dissemination of infection was severe in both cases, but none of the patients presented endocarditis. All isolates shared resistance to erythromycin and clindamycin (inducible macrolide resistance phenotype, iMLSb). The genomic analysis of one of the isolates indicated that it belongs to the human-associated CC398-MSSA clonal complex, an emerging lineage in our region. Whole genome sequencing enabled the characterization and differentiation of this clone from the livestock-associated CC398-MSSA lineage.
Authors
- Cristiana Spinelli (ORCID: https://orcid.org/0000-0002-4655-6173)
- Tomás Poklépovich (ORCID: https://orcid.org/0000-0002-0384-6066)
- Lucía Rago
- Gabriela Rubinstein
- Sabrina Di Gregorio (ORCID: https://orcid.org/0000-0003-3787-3318)
- María Sol Haim (ORCID: https://orcid.org/0000-0002-0118-1996)
- Marta Eugenia Mollerach (ORCID: https://orcid.org/0000-0002-5735-8471)
Institutions
- Universidad de Buenos Aires (AR)
- Administración Nacional de Laboratorios e Institutos de Salud (AR)
- Instituto de Química y Fisicoquímica Biológicas (AR)
- Universidad San Carlos (PY)
Publication Details
- Journal
- Revista Argentina de Microbiología
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.ram.2025.06.003
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Buenos Aires
- Agencia Nacional de Promoción Científica y Tecnológica
- Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires