Boosting the ventrolateral periaqueductal gray-ventral tegmental area pathway by disinhibition of group II mGluRs alleviates chronic restraint stress-induced depression-like behavior in mice
This provides the first direct evidence that blockade of mGlu2/3 receptors in the vlPAG ameliorates depression-like behavior, highlighting their role in regulating vlPAG-VTA neurocircuits implicated in MDD pathophysiology.
Authors
- Cheng‐Chun Wu (ORCID: https://orcid.org/0000-0002-7084-9208)
- Yu‐Cheng Ho (ORCID: https://orcid.org/0009-0009-6935-3502)
- Yu‐Ning Teng (ORCID: https://orcid.org/0000-0003-4364-7720)
- Yung‐Kuo Lee (ORCID: https://orcid.org/0000-0003-1638-8049)
- Ming Tatt Lee (ORCID: https://orcid.org/0000-0003-3957-2439)
- Tian‐Huei Chu (ORCID: https://orcid.org/0000-0003-1197-5754)
- Tien‐Wei Hsu (ORCID: https://orcid.org/0000-0003-4136-1251)
- Wei‐Hao Peng (ORCID: https://orcid.org/0000-0002-7524-1218)
- Yu-Yan Lan (ORCID: https://orcid.org/0000-0003-4436-2057)
Institutions
- Kaohsiung Medical University (TW)
- China Medical University (TW)
- National Tsing Hua University (TW)
- Kaohsiung Armed Forces General Hospital (TW)
- UCSI University (MY)
- I-Shou University (TW)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1177/02698811251351611
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Ministry of Higher Education, Malaysia
- E-Da Hospital
- National Science and Technology Council