The transcriptomic signature of <scp>DEPDC5 KO</scp> induced <scp>mTOR</scp> hyperactivation in human neurons and its response to rapamycin treatment
These new insights on the human gene network of DEPDC5 show evidence for pathological mechanisms that are not attenuated by the currently administered RAPA concentrations or that are independent of mTOR. These mechanisms should be considered as potential targets for future therapies.
Authors
- Karl Martin Klein (ORCID: https://orcid.org/0000-0002-6654-1665)
- Sophie von Brauchitsch (ORCID: https://orcid.org/0000-0001-8740-9279)
- Afsheen Yousaf (ORCID: https://orcid.org/0000-0002-8026-7332)
- Stefan Momma (ORCID: https://orcid.org/0000-0001-7816-5145)
- Evelyn Ullrich (ORCID: https://orcid.org/0000-0001-8530-1192)
- Felix Rosenow (ORCID: https://orcid.org/0000-0002-3989-7471)
- Jasmin K. Hefendehl (ORCID: https://orcid.org/0000-0001-8994-2536)
- Silvia Lindlar
- Denise Haslinger (ORCID: https://orcid.org/0000-0002-1859-4295)
- Christine M. Freitag (ORCID: https://orcid.org/0000-0001-9676-4782)
- Regina Waltes (ORCID: https://orcid.org/0000-0002-4388-6855)
- Mattson S. O. Jones (ORCID: https://orcid.org/0000-0002-3644-4530)
- Andreas G. Chiocchetti (ORCID: https://orcid.org/0000-0002-7329-9985)
- Andrea Rossi (ORCID: https://orcid.org/0000-0001-5863-6448)
- J. Ludwig
Institutions
- Goethe University Frankfurt (DE)
- Alberta Children's Hospital (CA)
- Leibniz Institute of Environmental Medicine (DE)
- University Hospital Frankfurt (DE)
- Frankfurt Cancer Institute (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Frankfurt University of Applied Sciences (DE)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1111/epi.18549
- Citations
- 1
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.82