Tumour progression shows decrease in PD‐L1 expression in matched metastases/primary uveal melanomas
While UM metastases had higher lymphocytic infiltrates than primary UM, PD-L1 showed a lower expression in metastases. We believe that the low effectiveness of ICI in the treatment of metastatic UM may be partly explained by the low PD-L1 expression. We propose that primary tumours may be more responsive to ICI therapy than metastases and could be targeted in a (neo)adjuvant setting for patients at high risk of developing metastases.
Authors
- Martine J. Jager (ORCID: https://orcid.org/0000-0003-2261-3820)
- Ellen Kapiteijn (ORCID: https://orcid.org/0000-0002-4814-6426)
- Robert M. Verdijk (ORCID: https://orcid.org/0000-0003-1437-214X)
- Maria Chiara Gelmi (ORCID: https://orcid.org/0000-0002-9099-009X)
- T. H. Khanh Vu (ORCID: https://orcid.org/0000-0003-1809-4001)
- Gülçin Gezgin
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
Publication Details
- Journal
- Acta Ophthalmologica
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1111/aos.17559
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bontius Stichting
- Oogfonds
- Stichting Blinden-Penning