Effects of Epigenetics on miRNAs and the Function of T Cells in Allergic Diseases

Especially with their inflammatory responses, immune T cells play a large role in the development and severity of allergic diseases.In recent studies, epigenetic modifications, specifically types that affect microRNAs (miRNAs), were shown to have the ability to significantly influence gene expression regulation in various T-cell subsets.Many epigenetic modification mechanisms, such as DNA methylation and histone acetylation, have been proven to successfully modify miRNAs along with T cell differentiation in allergic diseases.A secondary analysis was conducted using databases of ScienceDirect, Google Scholar, and PubMed to gather data.This article will explore the effects of epigenetic modifications that target miRNAs on T-cell function in allergic diseases such as atopic dermatitis, asthma, and chronic urticaria.Although these epigenetic methods can help noninflammatory regulatory T cells suppress proinflammatory T cells, the risks of these changes include mutations that worsen the allergic reaction.Because of this, researching the effects of epigenetics on T cells is crucial as it can lead to a deeper understanding of allergic inflammation and specific miRNAs affected by immune dysregulation, potentially aiding in future developments of more effective and longer-lasting treatments.