Exploration of the Medicinal Origin and Clinical Anti-Cancer Value of Wumei (Mume fructus)

Wumei is the nearly mature fruit of Prunus mume (Sieb.)Sieb.Et Zucc., a deciduous tree of the Rosaceae family.It possesses unique advantages and characteristics in anti-cancer properties.Thus, the study aims to examine the historical origins and evolution of traditional Chinese medicine Wumei (Mume fructus) and to investigate its potential anti-cancer effects using network pharmacology research techniques.This study uses network pharmacology techniques to examine the historical origins and evolution of Wumei (Mume fructus) and its potential anti-cancer effects.Initially, a comprehensive review of the plant's distribution, medicinal properties, and processing techniques was conducted.Active compounds of Wumei were identified using the TCMSP database, and the SwissTargetPrediction database was used to predict their potential targets.A protein-protein interaction network was established to investigate the primary targets and pathways involved in Wumei's anti-tumor mechanism.Eight effective components of Wumei were identified, predicting 282 potential targets.The PPI network includes key proteins such as VEGFA, SRC, AKT1, ESR1, and BCL2L1.Biological enrichment analysis indicates potential interactions with cancerrelated pathways, including the PI3K Akt, Rap1, Ras, and MAPK signaling pathways.Wumei targets various tumors, including medulloblastomas, astrocytomas, lymphomas, mesothelioma, prostate cancer, breast cancer, and head and neck cancers.Wumei is a traditional Chinese medicine with both medicinal and edible properties, offering diverse clinical health benefits.