Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus

Oncolytic viruses could provide a safe alternative for targeting aggressive tumors that evade standard therapies. While rodent protoparvoviruses are innocuous in non-cancerous cells, they carry out efficient cell killing in tumors. Differences in cell tropism and killing efficiency are determined by the viral capsid proteins; thus, structural studies provide insight into understanding the protoparvovirus infection in both wild-type and cancerous cells. Binding to extracellular sialic acid (SIA) initiates cell entry for protoparvoviruses H-1PV, MVMp, and this is also hypothesized for LuIII. This study investigates the structures of LuIII and H-1PV in the presence of their glycan receptors to identify and map the capsid loci that are responsible for this interaction. This knowledge may aid future capsid engineering to improve oncolytic targeting efficiency.

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Publication Details

Journal
Journal of Virology
Published
2025-07-24
DOI
https://doi.org/10.1128/jvi.00297-25
Citations
2
Primary Topic
Virus-based gene therapy research
Type
article
Field-Weighted Citation Impact
3.63

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article

Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus

Amriti Singh, Peter H. Seeberger, Lorena Geilen, Paul R. Chipman et al.
2 citations
Journal of Virology
Virus-based gene therapy research
3.63
article

Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus

Amriti Singh, Peter H. Seeberger, Lorena Geilen, Paul R. Chipman, Sujata Halder, Adam Misseldine, Mario Mietzsch, Robert McKenna, Jamie Heimburg‐Molinaro, Nikéa Pittman, Paulina Kapłonek, Antonette Bennett, Kevin Busuttil, Jon Zachary
article en
2 citations

Abstract

Oncolytic viruses could provide a safe alternative for targeting aggressive tumors that evade standard therapies. While rodent protoparvoviruses are innocuous in non-cancerous cells, they carry out efficient cell killing in tumors. Differences in cell tropism and killing efficiency are determined by the viral capsid proteins; thus, structural studies provide insight into understanding the protoparvovirus infection in both wild-type and cancerous cells. Binding to extracellular sialic acid (SIA) initiates cell entry for protoparvoviruses H-1PV, MVMp, and this is also hypothesized for LuIII. This study investigates the structures of LuIII and H-1PV in the presence of their glycan receptors to identify and map the capsid loci that are responsible for this interaction. This knowledge may aid future capsid engineering to improve oncolytic targeting efficiency.

Journal of VirologyVol. 99(8)
Beth Israel Deaconess Medical Center (US), University of Florida (US), Max Planck Institute of Colloids and Interfaces (DE), Freie Universität Berlin (DE)
National Institute of General Medical Sciences
Openalex Percentile: Top 7%
Virus-based gene therapy research
3.63
DOIOpen Access PDFOpenAlex
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Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus — Amriti Singh, Peter H. Seeberger, et al. · Journal of Virology (2025) | TGRS Research Map | TGRS