Synthesis of Cyclobuta[<i>b</i>]acetylindolines via Gold Photocatalysis
The [2 + 2] cycloaddition reaction constitutes a powerful tool for the construction of cyclobutane-fused scaffolds. A protocol for the intermolecular cycloaddition of 1-acetylindoles was developed where [Au(SIPr)Cbz] has proven indispensable for this purpose, while conventional photocatalysts, such as iridium and organic photosensitizers, have shown limited efficiency. Our findings unlocked the synthesis of cyclobutane-fused indolines, without any required substituent at the C2 or C3 position.
Authors
- Catherine S. J. Cazin (ORCID: https://orcid.org/0000-0002-9094-8131)
- Kristof Van Hecke (ORCID: https://orcid.org/0000-0002-2455-8856)
- Bholanath Maity (ORCID: https://orcid.org/0000-0001-5969-0112)
- Nestor Bracho Pozsoni (ORCID: https://orcid.org/0009-0004-3880-2487)
- Luigi Cavallo (ORCID: https://orcid.org/0000-0002-1398-338X)
- Miquel Gassiot i Matas
- Vladislav A. Voloshkin (ORCID: https://orcid.org/0000-0002-6176-7059)
- Sayan Dutta (ORCID: https://orcid.org/0000-0002-8232-5989)
- Roman V. Larkovich (ORCID: https://orcid.org/0000-0002-6907-7466)
- Steven P. Nolan (ORCID: https://orcid.org/0000-0001-9024-2035)
- Junying Wang (ORCID: https://orcid.org/0000-0002-7962-6641)
- Ihar E. Mikhnavets
Institutions
- Ghent University Hospital (BE)
- Centre for Sustainable Energy (GB)
- King Abdullah University of Science and Technology (SA)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c02294
- Citations
- 2
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Fonds Wetenschappelijk Onderzoek
- King Abdullah University of Science and Technology
- Universiteit Gent