Divergent and Selective Synthesis of Functionalized Fluoroalkenes through Switchable Photocatalytic Dialkylation/Cyclization of Alkenes
A switchable photocatalytic dialkylation/cyclization of alkenes with α-CF<sub>3</sub> alkenes and protic C(sp<sup>3</sup>)-H feedstocks was readily achieved by simply switching the commercially available base and/or its stoichiometry. This mild strategy enabled the divergent one-pot synthesis of diverse functionalized fluoroalkenes including gem-difluoroalkenes, monofluorocyclohexenes, and 2-fluoropyrrolines in a single operational step.
Authors
- Siping Wei (ORCID: https://orcid.org/0000-0002-1084-8772)
- Zhengchu Chen
- Min Dong (ORCID: https://orcid.org/0000-0001-6655-2818)
- Dong Yi (ORCID: https://orcid.org/0000-0002-8281-7860)
- Jialin Zhang (ORCID: https://orcid.org/0000-0001-6466-7558)
- Lei Yuan
- Hua Xia (ORCID: https://orcid.org/0000-0003-0923-6493)
- Yu Sha (ORCID: https://orcid.org/0000-0002-2621-7609)
- Zhaopo Geng
- Ying Xiong (ORCID: https://orcid.org/0009-0000-1747-2416)
Institutions
- Southwest Medical University (CN)
- Mianyang Central Hospital (CN)
- Analysis and Testing Centre (CN)
- Green Chemistry (PL)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1021/acs.joc.5c01215
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program