ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.
Authors
- Chenchen Feng
- Gaston Bonenfant (ORCID: https://orcid.org/0000-0002-0081-7470)
- John Steel (ORCID: https://orcid.org/0000-0003-1217-0990)
- Yasuko Hatta (ORCID: https://orcid.org/0009-0000-1024-3792)
- Gloria P. Larson (ORCID: https://orcid.org/0000-0001-5836-1499)
- Yujin Jung (ORCID: https://orcid.org/0000-0002-6541-6272)
- Bin Zhou (ORCID: https://orcid.org/0000-0002-1535-6283)
- Nannan Jiang (ORCID: https://orcid.org/0000-0003-3375-4805)
- Masato Hatta (ORCID: https://orcid.org/0000-0002-5532-2942)
- David E. Wentworth (ORCID: https://orcid.org/0000-0001-6310-1552)
- Dan Cui (ORCID: https://orcid.org/0009-0008-7100-8751)
- Brenda M. Calderon (ORCID: https://orcid.org/0000-0003-1130-0386)
- Ginger Atteberry
- Wei Wang (ORCID: https://orcid.org/0000-0001-7788-1895)
- Xiaoyu Fan (ORCID: https://orcid.org/0000-0001-5148-295X)
- Xudong Lin
- Li Wang (ORCID: https://orcid.org/0000-0003-3722-5986)
- Michael Currier
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3201/eid3108.241844
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40