Application of Mendelian randomization and bioinformatic analysis to construct a prognostic model for thyroid cancer and perform pan-cancer analysis
This study identified ALOX15B, TIAM1, and TMC6 as potential risk genes and JUN, PAPSS2, and RAP1GAP as protective genes in THCA. These genes may serve as promising biomarkers and therapeutic targets for THCA, offering novel insights into precision oncology.
Authors
- Ke Zheng (ORCID: https://orcid.org/0000-0001-5288-1805)
- Sunjie Yan (ORCID: https://orcid.org/0000-0002-9695-1307)
- Jiebin Lin
- Zhiyan Weng
- Zhenrun Zhan (ORCID: https://orcid.org/0000-0002-9369-4544)
- Ximei Shen (ORCID: https://orcid.org/0000-0003-0598-366X)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s12672-025-03222-7
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fujian Provincial Health Commission