<i>Scheffersomyces spartinae</i> Fungemia among Pediatric Patients, Pakistan, 2020–2024
Prevalence of emerging fungal infections is increasing, particularly among immunocompromised persons, children, and older persons. We report 108 cases of Scheffersomyces spartinae infection in pediatric patients from Karachi and other cities in Pakistan, of which 107 were identified from blood cultures. Cultures were initially misidentified as Clavispora lusitaniae by a biochemical assay before speciation as S. spartinae by whole-genome sequencing. All isolates were from children <12 years of age, and >69% were from children <1 month of age. Isolates were genetically distinct across regions of Pakistan; however, genetic diversity was low in isolates from patients in Karachi and nearby Nawabshah and had median differences of just 9 pairwise nucleotide variants. This study demonstrates S. spartinae is a potentially emerging pathogen in neonates and young infants in Pakistan. The findings highlight the limitations of phenotypic identification for detecting emerging fungal infections and underscore the value of molecular identification approaches.
Authors
- Judd F. Hultquist (ORCID: https://orcid.org/0000-0001-6424-4280)
- Egon Anderson Ozer (ORCID: https://orcid.org/0000-0002-7131-3691)
- Javaria Ashraf (ORCID: https://orcid.org/0000-0001-7326-5921)
- Charlesnika Tyon Evans (ORCID: https://orcid.org/0000-0002-0696-8288)
- Joveria Farooqi (ORCID: https://orcid.org/0000-0002-9921-4660)
- Noureen Saeed
- Erica Marie Hartmann (ORCID: https://orcid.org/0000-0002-0966-2014)
- Kauser Jabeen (ORCID: https://orcid.org/0000-0003-2497-7847)
- Ali Raza Bukhari (ORCID: https://orcid.org/0000-0001-7878-8959)
- Larry K. Kociolek (ORCID: https://orcid.org/0000-0002-8756-3417)
- Sadaf Zaka (ORCID: https://orcid.org/0009-0001-5024-1713)
- Ramón Lorenzo-Redondo (ORCID: https://orcid.org/0000-0002-5462-9483)
- Hassan Ghayas
- Mehreen Arshad (ORCID: https://orcid.org/0000-0002-7517-9274)
- Syed Faisal Mahmood (ORCID: https://orcid.org/0000-0002-3390-7659)
- Lacy M. Simons (ORCID: https://orcid.org/0000-0003-4041-6775)
- Zahra Hasan (ORCID: https://orcid.org/0000-0003-2263-236X)
- Sameer Patel (ORCID: https://orcid.org/0000-0002-3827-3560)
- Rumina Hasan (ORCID: https://orcid.org/0000-0002-6707-2231)
- Mohammad Hanif
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3201/eid3108.241604
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00