Meta-analysis and literature review on MRI diagnosis of cartilage invasion in laryngeal neoplasms

Background:To analyze the sensitivity and specificity of magnetic resonance imaging (MRI) in diagnosing cartilage invasion in laryngeal neoplasms.Materials and Methods: A comprehensive search for relevant studies was conducted in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and the Cochrane Trials Registry, with the search period extending until September 1, 2024.Sensitivity, specificity, and diagnostic likelihood ratio (DLR) were combined.Symmetrical Receiver Operating Characteristic (SROC) curves and Fagan nomograms were plotted.Metaregression and subgroup analyses were performed to identify heterogeneity sources.Results: A total of seven studies involving 418 participants were included.MRI demonstrated a sensitivity of 0.93 [95% CI: 0.89-0.96,I=0.00] and a specificity of 0.88 [95% CI: 0.81-0.92,I=70.36] for detecting cartilage invasion.The negative diagnostic likelihood ratio (DLR-) was 0.08 with a 95% confidence interval of 0.05 to 0.13.The Area Under Curve(AUC) of the SROC curve was 0.95 with a 95% confidence interval of 0.85 to 0.99.Leave-one-out sensitivity analysis validated the robustness of the results concerning heterogeneity, as subgroup analysis did not mitigate it.Deek's funnel plot showed a symmetrical distribution of studies around the regression line, indicating no significant publication bias (t=0.92,P=0.40).Conclusion: MRI provides a reliable diagnostic performance for cartilage invasion in Laryngeal Neoplasms.