High dosage accelerated intermittent theta burst stimulation without precision targeting and dosing in depression: an open-label pilot study
This pilot trial evidenced the antidepressant effect of a high dosage aiTBS protocol comparable with the Stanford Neuromodulation Therapy (SNT) approach but without individualized precision components. Its effectiveness appeared lower than previously reported for SNT. Randomized controlled trials should systematically investigate the contribution of precision components to the overall effectiveness of aiTBS in depression. This trial is a part of a real-world clinical study of non-invasive brain stimulation treatments conducted at our department (preregistered at DRKS-ID: DRKS00024776, drks.de).
Authors
- Gerrit Burkhardt (ORCID: https://orcid.org/0000-0003-3965-5664)
- Ulrike Vogelmann (ORCID: https://orcid.org/0000-0001-5005-0709)
- Lucia Bulubas (ORCID: https://orcid.org/0000-0002-5797-8742)
- Jonas Björklund (ORCID: https://orcid.org/0000-0003-2521-6679)
- Daniel Keeser (ORCID: https://orcid.org/0000-0002-0244-1024)
- André R. Brunoni (ORCID: https://orcid.org/0000-0002-6310-3571)
- Miaoxi Chen (ORCID: https://orcid.org/0009-0007-3991-153X)
- Frank Padberg (ORCID: https://orcid.org/0000-0001-7638-8310)
- Simone Weller (ORCID: https://orcid.org/0000-0002-5348-6513)
- Kai-Yen Chang
- Kristin Hagenah
Institutions
- Universidade de São Paulo (BR)
- German Centre for Cardiovascular Research (DE)
- Medizinische Zentrum für Gesundheit (DE)
- Max Planck Institute of Psychiatry (DE)
- Technical University of Munich (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s00406-025-02067-z
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00