RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular Osteoradionecrosis—study protocol for an open-label phase II randomised controlled superiority trial
RAPTOR is registered with the ISRCTN registry effective date 11th November 2022: Clinical trial of the non-surgical management of radiotherapy damage to the lower jaw ISRCTN34217298, and also registered with the European Clinical Trials Database (Eudra-CT 2022-000728-39).
Authors
- Anastasios N. Kanatas (ORCID: https://orcid.org/0000-0003-2025-748X)
- James McCaul (ORCID: https://orcid.org/0000-0001-7732-145X)
- Richard Jackson (ORCID: https://orcid.org/0000-0002-7814-5088)
- Julie Perry
- Ayten Basoglu
- Vinod Patel (ORCID: https://orcid.org/0000-0002-3709-5619)
- Richard Shaw (ORCID: https://orcid.org/0000-0002-5157-4042)
- Stefano Fedele (ORCID: https://orcid.org/0000-0001-9006-9412)
- Rebecca Tangney (ORCID: https://orcid.org/0009-0008-9573-6681)
- Mandeep S. Bajwa (ORCID: https://orcid.org/0000-0003-3135-754X)
- Chris Butterworth (ORCID: https://orcid.org/0000-0002-5025-7467)
- Ruth Knight (ORCID: https://orcid.org/0000-0001-6810-2845)
- Mererid Evans
- Jagtar Dhanda (ORCID: https://orcid.org/0000-0002-8753-3066)
- Vincent Killen
Institutions
- Brighton and Sussex Medical School (GB)
- Leeds General Infirmary (GB)
- St Thomas' Hospital (GB)
- University of Liverpool (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Velindre NHS Trust (GB)
- University of Surrey (GB)
- UCL Biomedical Research Centre (GB)
- Liverpool Womens NHS Foundation Trust (GB)
- Queen Elizabeth University Hospital (GB)
- Leeds Dental Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Trials
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s13063-025-08966-9
- Citations
- 1
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Cancer Research Institute
- National Cancer Research Institute
- National Institute for Health and Care Research
- Efficacy and Mechanism Evaluation Programme