Effectiveness of levonorgestrel-based intrauterine insemination system therapy combined with hysteroscopic electrosurgery and radiotherapy in the treatment of highly differentiated endometrial cancer

Background: Exploring the efficacy of levonorgestrel intrauterine contraceptive system combined with hysteroscopic resection for the treatment of early and highly differentiated endometrial cancer in young patients and its impact on reproductive function.Materials and Methods: According to the grouping method, the patients were divided into a single hysteroscopy group and a combined progesterone group, with 77 patients in each group.Among them, the single hysteroscopy group received hysteroscopic resection surgery, while the combined progesterone group received levonorgestrel intrauterine contraceptive system treatment on hysteroscopic resection surgery beside radiation.Results: After treatment, endometrial thickness, uterine volume and myoma volume were lower in the combined treatment group than in the intrauterine sustained release group (P<0.05); after treatment, estradiol, FSH and progesterone levels were lower in the combined treatment group compared with the intrauterine sustained release group (P<0.05); after treatment, Hb and VEGF levels were lower in the combined treatment group compared with the intrauterine sustained release group (P < 0.05); after treatment, compared with the intrauterine sustained release group, Hb and VEGF levels were lower in the combined treatment group (P<0.05);Compared with the intrauterine sustained release group, the dysmenorrhea score and CA125 expression level in the combined treatment group were lower (P<0.05);compared with the intrauterine sustained release group, the effective rate of the combined treatment group was higher (P<0.05).Conclusion: The application of mifepristone combined with levonorgestrel intrauterine sustained release system in the treatment of patients with uterine fibroids can effectively improve the symptoms of patients, alleviate clinical symptoms, alleviate dysmenorrhea, effectively inhibit the further development of the disease, reduce the expression level of CA125, improve the prognosis of patients, and have a significant therapeutic effect.