Primary parotid gland malignant melanoma complicated with lung and bone metastasis; a case report

Background: Malignant melanoma of the primary parotid gland (PGMM) is extremely rare, and most of the previous reports are case reports.This study describes the clinical and histological characteristics of a single case of PGMM.Materials and methods: The patient was diagnosed following the detection of a mass in the parotid region.Examination of the resected tissue specimens demonstrated cells with copious eosinophilic cytoplasm, significant pleomorphic in the nuclei, and distinct nucleoli.Immunohistochemical analysis was performed to measure HMB45, S-100, SOX-10, and Melan-A markers expression in tumor tissue.The clinicopathological features of a series of parotid gland malignant melanomas were analyzed.Results: Despite undergoing surgical intervention, immunotherapy, and targeted therapy, this case occurred distant metastases.The patient survived 2 years and 3 months after surgery due to multiple metastases throughout the body.Conclusion: This article reported the clinical characteristics of the case and provided an overview of primary PGMM cases documented over the last three decades.