Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry
Standard DNA NGS detects less than a quarter of NCs; RNA-based fusion testing, or NUT IHC/NUTM1 FISH, should be routine for suspected NC. NCs are enriched in co-occurring epigenetic, cell cycle, and DNA repair alterations, warranting further evaluation.
Authors
- Paul K. Paik (ORCID: https://orcid.org/0000-0002-9464-3984)
- Steven G. DuBois (ORCID: https://orcid.org/0000-0003-0882-738X)
- Sarina A. Piha‐Paul (ORCID: https://orcid.org/0000-0001-9455-1660)
- Glenn J. Hanna (ORCID: https://orcid.org/0000-0002-9969-2523)
- Robert C. Hsu (ORCID: https://orcid.org/0000-0003-3957-6106)
- Jia Luo (ORCID: https://orcid.org/0000-0003-3606-827X)
- Geoffrey Ira Shapiro (ORCID: https://orcid.org/0000-0002-3331-4095)
- Pasi Antero Janne (ORCID: https://orcid.org/0000-0002-7821-4928)
- Christopher Alexander French (ORCID: https://orcid.org/0000-0002-7434-4987)
- David Allen Barbie (ORCID: https://orcid.org/0000-0002-5422-4275)
- Navin R. Mahadevan (ORCID: https://orcid.org/0000-0002-6805-8861)
- Jamie E. Chaft (ORCID: https://orcid.org/0000-0002-5838-9982)
- Lynette M. Sholl (ORCID: https://orcid.org/0000-0002-9532-9735)
- Francesco Paoloni (ORCID: https://orcid.org/0000-0002-8992-3578)
- Justin J. Kim (ORCID: https://orcid.org/0009-0000-7393-3758)
- Sara A. Walton (ORCID: https://orcid.org/0009-0007-3755-0451)
- Jessica Haradon
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Cornell University (US)
- University of Michigan (US)
- Michigan United (US)
- Michigan Medicine (US)
- USC Norris Comprehensive Cancer Center (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1071
- Citations
- 6
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 4.84