Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry

Standard DNA NGS detects less than a quarter of NCs; RNA-based fusion testing, or NUT IHC/NUTM1 FISH, should be routine for suspected NC. NCs are enriched in co-occurring epigenetic, cell cycle, and DNA repair alterations, warranting further evaluation.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-07-24
DOI
https://doi.org/10.1158/1078-0432.ccr-25-1071
Citations
6
Primary Topic
Protein Degradation and Inhibitors
Type
article
Field-Weighted Citation Impact
4.84
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article

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry

Paul K. Paik, Steven G. DuBois, Sarina A. Piha‐Paul, Glenn J. Hanna et al.
6 citations
Clinical Cancer Research
Protein Degradation and Inhibitors
4.84
article

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry

Paul K. Paik, Steven G. DuBois, Sarina A. Piha‐Paul, Glenn J. Hanna, Robert C. Hsu, Jia Luo, Geoffrey Ira Shapiro, Pasi Antero Janne, Christopher Alexander French, David Allen Barbie, Navin R. Mahadevan, Jamie E. Chaft, Lynette M. Sholl, Francesco Paoloni, Justin J. Kim, Sara A. Walton, Jessica Haradon
article en
6 citations

Abstract

Standard DNA NGS detects less than a quarter of NCs; RNA-based fusion testing, or NUT IHC/NUTM1 FISH, should be routine for suspected NC. NCs are enriched in co-occurring epigenetic, cell cycle, and DNA repair alterations, warranting further evaluation.

Clinical Cancer ResearchVol. 31(18)
University of Southern California (US), Brigham and Women's Hospital (US), Memorial Sloan Kettering Cancer Center (US), The University of Texas MD Anderson Cancer Center (US), Cornell University (US), University of Michigan (US), Michigan United (US), Michigan Medicine (US), USC Norris Comprehensive Cancer Center (US), Dana-Farber Cancer Institute (US), Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
Good health and well-being
Openalex Percentile: Top 5%
Protein Degradation and Inhibitors
4.84
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