Elevated Plasma BDNF in Early Primary Biliary Cholangitis: Associations with Liver Fibrosis, IL-6, IL-18, Fatigue, and Cognitive Impairment
Plasma BDNF concentrations are elevated in early-stage PBC and inversely correlate with liver fibrosis severity. No significant associations were found with hepatocellular injury, cognitive function, or fatigue. These findings suggest that BDNF may play a protective role against hepatic fibrogenesis, or alternatively, that BDNF concentrations may decline with advancing liver disease. Further studies are needed to clarify its significance in PBC.
Authors
- Paweł Rogalski (ORCID: https://orcid.org/0000-0002-1884-2500)
- Dagmara Bogdanowska-Charkiewicz (ORCID: https://orcid.org/0000-0001-9034-9238)
- Magdalena Rogalska (ORCID: https://orcid.org/0000-0002-9895-9361)
- J Janica (ORCID: https://orcid.org/0000-0001-8448-3158)
- Piotr Zabielski (ORCID: https://orcid.org/0000-0002-4901-5217)
- Kamila Roszczyc-Owsiejczuk (ORCID: https://orcid.org/0000-0001-5296-5582)
- A Dâbrowski (ORCID: https://orcid.org/0000-0002-5996-394X)
- Sławomir Ławicki (ORCID: https://orcid.org/0000-0001-6747-2123)
- Robert Flisiak (ORCID: https://orcid.org/0000-0003-3394-1635)
- Agnieszka Błachnio‐Zabielska (ORCID: https://orcid.org/0000-0002-8055-0576)
- Aleksandra Andrzejuk
Institutions
- Medical University of Białystok (PL)
- Medical University of Silesia (PL)
- Medical University of Warsaw (PL)
- Institute of Medical Microbiology and Hygiene (DE)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3390/ijms26157142
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Medyczny w Bialymstoku