Microbiome-derived reactivation of mycophenolate explains variations in enterohepatic recirculation in kidney transplant recipients
We highlight for the first time that the ex vivo determined reactivation rate of MPA explains the variation of enterohepatic recirculation, emphasizing the important role of F. prausnitzii in this process. More broadly, our findings suggest that the gut microbiome significantly influences the degree of enterohepatic recirculation of MPA, providing valuable insights that could be relevant for optimizing individualized immunosuppressive drug dosing in transplant patients. Video Abstract.
Authors
- Anders Åsberg (ORCID: https://orcid.org/0000-0002-0628-1769)
- Ida Robertsen (ORCID: https://orcid.org/0000-0001-9401-7716)
- Eric J. de Muinck (ORCID: https://orcid.org/0000-0001-5606-3172)
- Karsten Midtvedt (ORCID: https://orcid.org/0000-0002-3302-1110)
- Ole Martin Drevland (ORCID: https://orcid.org/0000-0002-0413-1548)
- Marta Hammerstad (ORCID: https://orcid.org/0000-0003-0872-3441)
- Kine Eide Kvitne (ORCID: https://orcid.org/0000-0001-8118-7660)
- Pål Trosvik
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- University of California San Diego (US)
Publication Details
- Journal
- Microbiome
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s40168-025-02142-6
- Citations
- 7
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.90
Funders
- Universitetet i Oslo
- Norges Forskningsråd